02283nas a2200457   4500000000100000008004100001260001300042653002500055653001100080653001900091653002000110653003800130653001500168653001100183653001900194653001200213653002000225653000900245653001500254653003600269653003000305100001500335700001600350700002100366700002100387700001500408700001500423700001500438700001500453700002000468700001600488700001900504700001400523245013100537856006200668300001000730490000600740050001600746520104900762022001401811       2004                            d  c2004 Nov10aConfidence Intervals10aFemale10aGene Frequency10aGenetic Markers10aGenetic Predisposition to Disease10aHaplotypes10aHumans10aInterleukin-1010aleprosy10aLogistic Models10aMale10aOdds Ratio10aPolymorphism, Single Nucleotide10aPromoter Regions, Genetic1 aMoraes M O1 aPacheco A G1 aSchonkeren J J M1 aVanderborght P R1 aNery J A C1 aSantos A R1 aMoraes M E1 aMoraes J R1 aOttenhoff T H M1 aSampaio E P1 aHuizinga T W J1 aSarno E N00aInterleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy.  uhttp://www.nature.com/gene/journal/v5/n7/pdf/6364122a.pdf  a592-50 v5  aMORAES 20043 a<p>We have determined IL-10 promoter genotypes of five single-nucleotide polymorphisms (SNPs): T-3575A, A-2849G, C-2763A, -A-1082G and C-819T. The haplotype frequencies were defined in healthy subjects compared to leprosy patients, and analyzed for their occurrence in multi- (MB) vs paucibacillary (PB) as severe and mild forms of leprosy, respectively. Haplotypes defined by three SNP positions (-3575, -2849 and -2763) captured significant differences between controls and patients (P=0.04). The haplotype carrying -3575A, -2849G and -2763C was associated with resistance to leprosy and to the development of severe forms of the disease using either a binomial (controls vs cases, P=0.005, OR=0.35, CI=0.13-0.91) or ordinal (controls vs PB vs MB, P=0.006, OR=0.32, CI=0.12-0.83) model. By contrast, the IL-10 haplotype -3575T/-2849A/-2763C was found to be associated with susceptibility to leprosy per se (P=0.027, OR=2.37, CI=1.04-5.39), but not leprosy type. The data suggest that the IL-10 locus contributes to the outcome of leprosy.</p>  a1466-4879