01462nas a2200289   4500000000100000008004100001260001300042653001000055653001200065653001200077653002700089653001100116653002300127653001200150653001600162653000900178653001100187100001400198700001500212700001500227245005000242300001000292490000700302050003200309520081700341022001401158       1976                            d  c1976 Jul10aAdult10aAnimals10aDapsone10aGraft vs Host Reaction10aHumans10aImmunity, Cellular10aleprosy10aLymphocytes10aMice10aSpleen1 aMehra N K1 aDasgupta A1 aVaidya M C00aAn evaluation of the immune state in leprosy.  a231-70 v48  aInfolep Library - available3 a<p>An evaluation of the immune state in leprosy was done by the application of a system of graft-versus-host reaction. Peripheral blood lymphocytes obtained from patients with different forms of leprosy and from normal healthy individuals were injected intravenously into the irradiated mice. The rate of blast transformation of the donor cells was measured by the radio-active thymidine uptake. The number of cells labelled with tritiated-thymidine was much higher in the normal individuals and patients with tuberculoid leprosy than in the patients with lepromatous leprosy with the borderline group placed in between the two. However, following successful treatment with DDS, an increased responsiveness and active DNA synthesis could be observed in the previously less responsive lepromatous lymphocytes.</p>  a0024-1024