01516nas a2200325   4500000000100000008004100001260000900042653001200051653002700063653001100090653001000101653001200111653001600123653000900139653001700148653002500165653002200190653001700212653002200229100001200251700001600263700001300279700001100292700001600303245007900319300001000398490000700408520076100415022001401176       1992                            d  c199210aAnimals10aDisease Models, Animal10aHumans10aLatex10aleprosy10aMacrophages10aMice10aMicrospheres10aMycobacterium leprae10aPeritoneal Cavity10aPhagocytosis10aRespiratory Burst1 aKohli M1 aVaishnavi C1 aJaswal S1 aKaur S1 aGanguly N K00aRespiratory burst metabolic status of macrophages in experimental leprosy.  a201-60 v363 a<p>Peritoneal macrophages from uninfected controls and Mycobacterium leprae infected Swiss albino mice were studied for their respiratory burst (RB) activity at different time intervals. The RB metabolic activity of macrophages declined significantly after 3 month infection using latex (p less than 0.001) and M. leprae (p less than 0.01) as stimuli. However, significant rise (p less than 0.001) in the oxidative metabolic activity was seen at 6 and 9 months postinfection period on stimulation with both the stimuli. The sharp rise in the oxidative metabolic status at peak period of infection in the experimental animals suggests that the macrophages are functionally normal though M. leprae is unable to trigger the respiratory burst sufficiently.</p>  a0022-1732