01987nas a2200493   4500000000100000008004100001260001300042653002500055653001700080653001800097653002200115653001800137653003700155653001400192653001600206653001100222653002500233653002100258653001200279653002000291653001200311653002800323653002900351653002500380653001400405653002300419653001800442100001300460700001500473700001300488700001300501700001400514700001000528700001500538700001500553700001500568700001600583700001400599245010200613300001000715490000800725520074600733022001401479       2004                            d  c2004 Mar10aAntigen Presentation10aAntigens, CD10aAntigens, CD110aAntigens, Surface10aCell Division10aDose-Response Relationship, Drug10aEpidermis10aFetal Blood10aHumans10aImmunohistochemistry10aLangerhans Cells10aLectins10aLectins, C-Type10aleprosy10aMannose-Binding Lectins10aMicroscopy, Fluorescence10aMycobacterium leprae10aPhenotype10aReceptors, Antigen10aT-Lymphocytes1 aHunger R1 aSieling PA1 aOchoa MT1 aSugaya M1 aBurdick A1 aRea T1 aBrennan PJ1 aBelisle JT1 aBlauvelt A1 aPorcelli SA1 aModlin RL00aLangerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.  a701-80 v1133 a<p>Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted and langerin-dependent manner. LC-like DCs were more efficient at CD1a-restricted antigen presentation than monocyte-derived DCs. LCs in leprosy lesions coexpress CD1a and langerin, placing LCs in position to efficiently present a subset of antigens to T cells as part of the host response to human infectious disease.</p>  a0021-9738