01582nas a2200385   4500000000100000008004100001260001300042653003200055653001100087653002000098653003800118653001100156653001200167653001100179653000900190653001300199653002400212100001400236700001400250700001300264700001400277700001600291700001900307700001800326700001400344700001200358700001500370245008700385856006200472300001000534490000600544050001700550520061500567022001401182       2004                            d  c2004 May10aChromosomes, Human, Pair 2110aFemale10aGenetic Linkage10aGenetic Predisposition to Disease10aHumans10aleprosy10aMalawi10aMale10aPedigree10aRegression Analysis1 aWallace C1 aFitness J1 aHennig B1 aSichali L1 aMwaungulu L1 aPonnighaus J M1 aWarndorff D K1 aClayton D1 aFine PE1 aHill A V S00aLinkage analysis of susceptibility to leprosy type using an IBD regression method.  uhttp://www.nature.com/gene/journal/v5/n3/pdf/6364062a.pdf  a221-50 v5  aWALLACE 20043 a<p>Leprosy is a chronic disease caused by infection with Mycobacterium leprae, which is manifested across a wide clinical spectrum. There is evidence that susceptibility both to leprosy per se and to the clinical type of leprosy is influenced by host genetic factors. This paper describes the application of an identity by descent regression search for genetic determinants of leprosy type among families from Karonga District, Northern Malawi. Suggestive evidence was found for linkage to leprosy type on chr 21q22 (P<0.001). The methodological implications of the approach and the findings are discussed.</p>  a1466-4879