01191nas a2200289   4500000000100000008004100001260001300042653001200055653002300067653001900090653001300109653001100122653001200133653002600145653002500171653003000196653002600226653001500252653001700267100001500284700001200299245004500311300000900356490000700365520051500372022001400887       2004                            d  c2004 Feb10aAnimals10aBacterial Proteins10aDNA, Bacterial10agenotype10aHumans10aleprosy10aMinisatellite Repeats10aMycobacterium leprae10apolymerase chain reaction10aPolymorphism, Genetic10aPrevalence10aSigma Factor1 aMatsuoka M1 aZhang L00a[Molecular epidemiology of the leprosy].  a7-140 v733 a<p>Application of molecular biological techniques to the epidemiological study of leprosy is described. Studies of detecting Mycobacterium leprae DNA in samples of the nasal mucus are discussed in terms of the epidemiology and the significance of high prevalence. Epidemiological studies on the transmission of leprosy and correlation between geographic distribution of different M. leprae rpoT genotypes and prehistoric spread of the leprosy by genotyping based on the genomic polymorphism are introduced.</p>  a1342-3681