01329nas a2200301   4500000000100000008004100001260001300042653001000055653001200065653003300077653003300110653001100143653001600154653001100170653002200181653001600203653002800219653001900247653002200266653001300288653001600301100001500317245009000332300001000422490000700432520057400439022001401013       1993                            d  c1993 Oct10aAdult10aAnimals10aDermatitis, Allergic Contact10aDesensitization, Immunologic10aFemale10aGuinea Pigs10aHumans10aIntradermal Tests10aPatch Tests10aPentacyclic Triterpenes10aPlant Extracts10aPlants, Medicinal10aTerpenes10aTriterpenes1 aHausen B M00aCentella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer.  a175-90 v293 a<p>The sensitizing capacity of Centella asiatica (raw extract) and its triterpenic constituents asiaticoside, asiatic acid and madecassic acid has been studied in guinea pigs. The extract itself as well as the 3 acids were found to be very weak sensitizers. Centella asiatica extract is used effectively in the treatment of keloids, leg ulcers, phlebitis, slow-healing wounds, leprosy, surgical lesions, striae distensae and cellulitis. Although applied frequently to damaged skin, the risk of acquiring contact sensitivity to this plant or its constituents is low.</p>  a0105-1873