01668nas a2200289   4500000000100000008004100001260001300042653001200055653002700067653002400094653001100118653001200129653000900141653002500150653002300175653001300198653003900211653001800250100001300268700001200281245016200293856004100455300001100496490000700507520085000514022001401364       2003                            d  c2003 Dec10aAnimals10aDisease Models, Animal10aDisease Progression10aHumans10aleprosy10aMice10aMycobacterium leprae10aNerve Degeneration10aNeuritis10aPeripheral Nervous System Diseases10aSchwann Cells1 aBirdi TJ1 aAntia N00aMechanisms involved in peripheral nerve damage in leprosy with special reference to insights obtained from in vitro studies and the experimental mouse model.  uhttp://ila.ilsl.br/pdfs/v71n4a05.pdf  a345-540 v713 a<p>The histopathological observations of Khanolkar and Iyer, that M. leprae has a predeliction for nerves, first highlighted the central role of peripheral nerves in the pathology of leprosy. It is now well recognized that nerve damage in leprosy will still continue to be an important problem in control and rehabilitation despite the presence of more efficient therapy. The multiplicity of mechanisms postulated, identified, and demonstrated in the last three decades has received little recognition from the scientific community at large. This review is therefore an attempt to collate these multiple studies on mechanisms of nerve damage into a cohesive analysis, which would facilitate the design of future studies. The objective of this review is to focus therefore only on studies which serve to illustrate mechanisms of nerve damage.</p>  a0148-916X