02837nas a2200373   4500000000100000008004100001260001300042653001000055653002800065653003000093653001200123653001100135653001600146653001000162653002300172653001200195653001600207653001800223653001000241653003300251653001700284653000900301100001100310700001800321700001200339700001000351700001200361245005800373856004100431300001000472490000700482520196000489022001402449       2003                            d  c2003 Dec10aAdult10aCross-Sectional Studies10aDrug Therapy, Combination10aFingers10aHumans10aHypesthesia10aIndia10aLeprostatic Agents10aleprosy10aMiddle Aged10aNail Diseases10aNails10aPeripheral Vascular Diseases10aTime Factors10aToes1 aKaur I1 aChakrabarti A1 aDogra S1 aRai R1 aKumar B00aNail involvement in leprosy: a study of 300 patients.  uhttp://ila.ilsl.br/pdfs/v71n4a02.pdf  a320-70 v713 a<p>Three hundred leprosy patients were recruited to study the pattern and frequency of nail changes. Nail changes, like longitudinal ridging in finger nails, transverse striations involving both finger and toe nails etc. which occurred with similar frequency in the PB and MB patients in comparison with the control group, were excluded from the analysis. Out of a total number of 150 PB patients, 84 (56%) showed nail changes. Fifty-eight (38.6%) patients showed changes in the finger nails, with an average of 3.2 involved nails per patient. Fifty-three (35.3%) patients showed changes in the toe nails, with an average of 3.0 nails per patient. The most common change observed was longitudinal melanonychia (32.4%) in the finger nails and longitudinal ridging (46.3%) in the toe nails.In comparison, 131/150 (87.3%) MB patients showed nail changes. Finger nail changes were seen in 102 (68%) patients with an average of 5.5 nails affected per patient. Changes in toe nails were seen in 116 (77.3%) patients, with an average of 6.0 nails involved per patient. The most common nail change observed was longitudinal melanonychia in 89/523, (17%) of the total involved finger nails and subungual hyperkeratosis in 164/702, (23.4%) of the total toe nails involvement. Out of a total of 32 colony patients, 31 (96.9%) showed nail changes both in finger and toe nails with an average of 7.9 and 8.4 affected nails per patient, respectively. The most common nail change observed was rudimentary nail(s) on fingers (29%) and toes (21.1%). Among MB patients, a significantly higher number had finger nail involvement in LL group. The frequency of nail involvement for both fingers and toes was significantly greater in LL as compared to BL group of patients. The frequency of nail involvement was significantly more in patients having disease for more than 5 years and in those having trophic changes secondary to loss of sensations and impaired circulation.</p>  a0148-916X