01487nas a2200265   4500000000100000008004100001260001600042653001200058653002000070653002600090653002600116653001200142653001300154653002500167653004600192653003400238100001300272700001400285700001300299245013000312300001100442490000600453520074800459022001401207       2004                            d  c2004 Jan 0110aAnimals10aCercocebus atys10aHistory, 20th Century10aHistory, 21st Century10aleprosy10aLymphoma10aMycobacterium leprae10aSimian Acquired Immunodeficiency Syndrome10aSimian immunodeficiency virus1 aGormus B1 aMartin LN1 aBaskin G00aA brief history of the discovery of natural simian immunodeficiency virus (SIV) infections in captive sooty mangabey monkeys.  a216-240 v93 a<p>Experimental leprosy studies using Mycobacterium leprae inoculum isolated from a sooty mangabey monkey (SMM) resulted in the accidental discovery that SMM's asymptomatically carry simian immunodeficiency virus (SIV) that is pathogenic in macaques. We showed that the SMM virus, SIVDelta, was antigenically related to SIVmac, which had been identified in macaques, and to the human immunodeficiency virus (HIV). Similar asymptomatic natural SIV infections had been reported in African green monkeys (AGM). Our results together with observations of others led us to propose that both SIVmac and SIVDelta originated in SMM and that SIV emerged in humans as a result of early African nonhuman primate SIV trans-species infections in humans.</p>  a1093-9946