01377nas a2200385   4500000000100000008004100001260001300042653001200055653002300067653001600090653002700106653004400133653003800177653001100215653003000226653002300256653002100279653002300300653002900323653001200352653000900364653002400373653002400397653002500421653003100446653000900477653001700486653001600503100001800519245008800537300001000625490000700635520033500642022001400977       1992                            d  c1992 Sep10aAnimals10aBacterial Vaccines10aBCG Vaccine10aDisease Susceptibility10aDose-Response Relationship, Immunologic10aGenetic Predisposition to Disease10aHumans10aHypersensitivity, Delayed10aImmunity, Cellular10aImmunity, Innate10aLeishmania tropica10aLeishmaniasis, Cutaneous10aleprosy10aMice10aMice, Inbred BALB C10aMycobacterium bovis10aMycobacterium leprae10aMycobacterium tuberculosis10aRats10aTuberculosis10aVaccination1 aBretscher P A00aA strategy to improve the efficacy of vaccination against tuberculosis and leprosy.  a342-50 v133 a<p>The pathogens responsible for leprosy, tuberculosis and the leishmaniases can induce different classes of immunity, but protection is provided only by a cell-mediated response. Here, Peter Bretscher proposes a strategy to achieve an immunological imprint that ensures a stable cell-mediated response upon natural infection.</p>  a0167-5699