02126nas a2200385   4500000000100000008004100001260001300042653001500055653001000070653001000080653001700090653001100107653001100118653001400129653001200143653000900155653001400164653001800178653001300196653002200209100001500231700001500246700002100261700001500282700001400297700001500311700001300326700001600339245012900355856004100484300001100525490000700536520118300543022001401726       1992                            d  c1992 Sep10aAdolescent10aAdult10aChild10aDosage Forms10aFemale10aHumans10aIncidence10aleprosy10aMale10aPolynesia10aPremedication10aRifampin10aTreatment Outcome1 aCartel J L1 aChanteau S1 aMoulia-Pelat J P1 aPlichart R1 aGlaziou P1 aBoutin J P1 aRoux J F1 aGrosset J H00aChemoprophylaxis of leprosy with a single dose of 25 mg per kg rifampin in the southern Marquesas; results after four years.  uhttp://ila.ilsl.br/pdfs/v60n3a11.pdf  a416-200 v603 a<p>In January-February 1988, a program of chemoprophylaxis for leprosy, using a single 25 mg/kg dose of rifampin, was conducted among 2786 (98.7%) inhabitants of the Southern Marquesas and 3144 South Marquesan "emigrants" and their families. Among the treated population, during the 4 years which followed the implementation of the program, two leprosy patients were detected, one of whom can be considered as a failure of chemoprophylaxis because she was not known by the leprosy control unit. During the same period (1988-1991), a decrease in detection rates for leprosy in the entire French Polynesian population has been observed, an event which makes the interpretation of these findings very difficult. Nevertheless, according to presently available data, the effectiveness of chemoprophylaxis with a single dose of 25 mg/kg rifampin is estimated to be about 40% to 50%. When considering not only the results of the present study but also the financial and logistic constraints raised by such a program, one is led to the conclusion that chemoprophylaxis, even with a single dose of rifampin, is not likely to become an effective component of leprosy control programs.</p>  a0148-916X