01669nas a2200289   4500000000100000008004100001260000900042653003000051653002000081653003800101653002000139653001100159653001200170653001200182653003700194653002700231653002600258653001700284100001200301700001400313700001100327245005500338300001100393490000700404520095400411022001401365       2003                            d  c200310aCation Transport Proteins10aGenetic Linkage10aGenetic Predisposition to Disease10aHLA-DR2 Antigen10aHumans10aLaminin10aleprosy10aMajor Histocompatibility Complex10aMannose-Binding Lectin10aReceptors, Calcitriol10aTuberculosis1 aRemus N1 aAlcaïs A1 aAbel L00aHuman genetics of common mycobacterial infections.  a109-290 v283 a<p>There is increasing interest in and understanding of the role of human genetic factors controlling susceptibility/resistance to infectious diseases. This is of particular importance for the two most common mycobacterial infections, tuberculosis and leprosy, because this will allow a genetic dissection of antimycobacterial immunity and should open new fields of preventive and therapeutic measures. In this review we will initially discuss various methods of genetic epidemiology that have been and are being developed to identify human genes controlling infectious diseases, and then illustrate the findings obtained in the numerous studies performed in tuberculosis and leprosy. Although the most convincing results were observed for HLA-DR2 and NRAMP1 (or a closely linked gene) in pulmonary tuberculosis and leprosy subtypes and for a 10p13 locus in paucibacillary leprosy, the molecular basis of their effects remains to be established.</p>  a0257-277X