02646nas a2200301   4500000000100000008004100001260001300042653001900055653002100074653002800095653003800123653004000161653002200201653001100223653002500234653001000259653001400269653001800283653000900301653002000310653003000330100001500360245007800375300001100453490000700464520185900471022001402330       2008                            d  c2008 Sep10aBiopsy, Needle10aChild, Preschool10aDermatitis, Exfoliative10aEnzyme-Linked Immunosorbent Assay10aEuropean Continental Ancestry Group10aFollow-Up Studies10aHumans10aImmunohistochemistry10aIndia10aKeratosis10aLichen Planus10aMale10aRisk Assessment10aSeverity of Illness Index1 aGhorpade A00aKeratosis lichenoides chronica in an Indian child following erythroderma.  a939-410 v473 a<p>A 4-year-old boy presented with mildly itchy, linear, skin lesions over the trunk, arms, and face of 3 months' duration. He had previously been admitted to a private hospital for generalized exfoliation of the skin following drug intake for fever and throat pain. The nature of the drugs was not known. The exfoliative dermatitis was treated with oral prednisolone, 10 mg daily, tapered over 3 weeks. No further topical or oral medication was given. The present skin lesions started 1 month after the cessation of the steroids. There was no family history of skin lesions, voice changes, or systemic complaints. Cutaneous examination showed multiple violaceous, linear, reticulate ridges with adherent scaling over the chest, back, and neck. There were scaly, flat-topped papules over the extensor aspects of both upper arms and the buttocks, and scaly plaques over the cheeks (Figs 1a-d and 2a,b). The scalp showed diffuse greasy scaling. There were no oral, genital, axillary, or eye lesions. The nails were normal. Systemic examination did not reveal any abnormal finding. Routine hematologic investigations, liver and kidney function tests, tests for hepatitis B and C, and enzyme-linked immunosorbent assay (ELISA) for HIV were normal. Histopathology from skin lesions on the back revealed hyperkeratosis, patchy parakeratosis, follicular plugging, alternating irregular acanthosis and epidermal thinning, basal cell degeneration, and a band-like inflammatory infiltrate of lymphocytes, histiocytes, and a few plasma cells (Fig. 3). Based on the classical clinical features and histopathology, keratosis lichenoides chronica was diagnosed, and topical 1% hydrocortisone acetate cream, twice daily, was prescribed. There was slight relief of pruritus at a follow-up visit after 3 weeks; however, the patient was subsequently lost to follow-up.</p>  a1365-4632