01448nas a2200289   4500000000100000008004100001260001300042653000900055653003000064653002300094653001100117653001000128653002300138653001200161653000900173653001700182653002200199100001600221700001500237700001300252700001500265245005100280300001100331490000700342520079500349022001401144       2003                            d  c2003 Aug10aAged10aDrug Therapy, Combination10aHospitals, General10aHumans10aJapan10aLeprostatic Agents10aleprosy10aMale10aPrednisolone10aTreatment Outcome1 aShirasaki F1 aTakehara K1 aTakata M1 aNamisato M00a[A case of lepromatous type Hansen's disease].  a267-700 v723 a<p>A 68 year-old male presented with painful swelling in the extremities and disseminated small brownish nodules over his entire body. A histological examination of the skin nodules showed multiple granuloma and a thickened peripheral nerve bundle surrounded with foamy macrophages and a few lymphocytes. Fite stain revealed numerous acid fast bacilli within the cytoplasm of the foamy cells. A diagnosis of lepromatous leprosy was thus made and multi-drug therapy following the Japanese guideline with DDS, rifampicin and clofazimine was started. The clinical features improved, and the morphological index decreased after undergoing chemotherapy. Although a severe type 1 reaction developed after four months of treatment, he was treated with oral prednisolone at a dose of 40 mg/day.</p>  a1342-3681