01465nas a2200301   4500000000100000008004100001260001300042653002200055653001200077653002600089653001200115653001600127653001200143653002400155653001200179653000900191653001200200653001300212653001500225653001100240100001300251700001300264245009000277300001000367490000700377520076500384022001401149       1960                            d  c1960 Mar10aAniline Compounds10aAnimals10aBiochemical Phenomena10aDapsone10aGuinea Pigs10aleprosy10aOxidation-Reduction10aRabbits10aRats10aSafrole10aSulfones10aSulfoxides10aSulfur1 aLEVI A A1 aSNOW G A00aMetabolism and excretion of di(p-aminophenyl) sulphoxide in different animal species.  a160-40 v153 a<p>Rabbits, rats and guinea-pigs were treated with di(p-aminophenyl) sulphoxide and their urines examined by an analytical method which permits the simultaneous determination of this compound and of dapsone [di(p-aminophenyl) sulphone] which is a possible product of metabolic oxidation. The method gives for each drug the total of free compound plus acid-labile conjugates. All three species excreted unchanged drug together with dapsone. With rats and guinea-pigs about 33% of the excretion is dapsone, but with rabbits only 6 to 12%. The rate of combined excretion is much greater in rabbits than in the other two species. These results are discussed in relation to the significance of di(p-aminophenyl) sulphoxide as a drug in the treatment of leprosy.</p>  a0366-0826