02098nas a2200433   4500000000100000008004100001260001700042653002400059653001500083653001000098653002200108653001000130653002100140653001100161653001200172653001800184653001100202653004600213653001100259653001000270653001100280653001900291653000900310653001600319653001600335653001300351100001400364700001600378700001500394700001600409700001000425700001400435700001200449245008500461300001100546490000800557520108500565022001401650       1977                            d  c1977 Sep-Oct10aAcute Kidney Injury10aAdolescent10aAdult10aAnemia, Hemolytic10aChild10aChild, Preschool10aCopper10aDapsone10aEthnic Groups10aFemale10aGlucosephosphate Dehydrogenase Deficiency10aHumans10aIndia10aInfant10aKidney Tubules10aMale10aMiddle Aged10aSnake Bites10aSulfates1 aChugh K S1 aSinghal P C1 aSharma B K1 aMahakur A C1 aPal Y1 aDatta B N1 aDas K C00aAcute renal failure due to intravascular hemolysis in the North Indian patients.  a139-460 v2743 a<p>Acute renal failure due to intravascular hemolysis is a common clinical problem in North Indian patients. It constituted 21.5 percent of 325 patients dialyzed for acute renal failure over an 11-year period at Chandigarh. Thirty patients had developed acute intravascular hemolysis in association with erythrocyte glucose-6 phosphate dehydrogenase (G-6PD) deficiency, 17 due to copper sulphate intoxication and 8 due to envenomation by snakes. Less frequent causes were insect stings, incompatible blood transfusion, intake of anti-leprosy drug--dapsone in non-G-6PD-deficient patients, and mercuric chloride toxicity in two patients each; naphthalene poisoning in one; and uncertain causes in six patients. Renal histology was available in 55 patients. Acute tubular necrosis was seen in 54 and bilateral diffuse cortical necrosis in one patient. Fifty patients (71.43 percent) survived and 20(28.6 percent) diet. G-6PD erythrocyte deficiency, which is present in 4.5 percent of the North Indian population, was the most frequent cause of acute renal failure in this group.</p>  a0002-9629