01702nas a2200289   4500000000100000008004100001260001300042653002400055653001500079653001000094653001100104653001100115653001200126653001600138653000900154653001600163100001500179700002100194700001100215700001200226700001400238245010500252300000900357490000700366520102500373022001401398       1992                            d  c1992 Jan10aAdenosine Deaminase10aAdolescent10aAdult10aFemale10aHumans10aleprosy10aLymphocytes10aMale10aMiddle Aged1 aSehgal V N1 aBhattacharya S N1 aShah Y1 aRao Y N1 aGupta C K00aLymphocyte adenosine deaminase activity (L-ADA) in leprosy, during and after treatment of reactions.  a20-30 v173 a<p>Twenty-five patients with type 1 (lepra) and type 2 (E.N.L.) leprosy reactions were studied for lymphocyte adenosine deaminase activity (L-ADA), during and after treatment of the reactions, using a standard technique, in order to establish its pattern and if possible, its value in assessing the course of reactions. The results were compared with those from 30 control subjects, comprising 10 normal healthy adults, 10 patients with borderline tuberculoid (BT) leprosy, four patients with borderline lepromatous (BL) leprosy and six patients with lepromatous (LL) leprosy. The level of L-ADA in the leprosy controls was higher than that of normal healthy subjects. The L-ADA values in patients with different types of reactions were about 10-fold higher than those obtained from leprosy controls, emphasizing a possible role in assessing reactions in leprosy. However, there was no significant variation in L-ADA levels, either between the various leprosy controls or reaction groups, before and after treatment.</p>  a0307-6938