01788nas a2200313   4500000000100000008004100001260001700042653001000059653001200069653001200081653003100093653001100124653001100135653001200146653000900158653000900167653002500176100001500201700001900216700001700235700001500252700001200267245012200279300001100401490000700412050003200419520100900451022001401460       1984                            d  c1984 Jul-Sep10aAdult10aAnimals10aDapsone10aDrug Resistance, Microbial10aFemale10aHumans10aleprosy10aMale10aMice10aMycobacterium leprae1 aBhatia V N1 aBalakrishnan S1 aSeshadri P S1 aNeelan P N1 aRoy R G00aDapsone resistance in patients attending Central Leprosy Teaching and Research Institute, Chengalpattu (South India).  a587-940 v56  aInfolep Library - available3 a<p>The Central Leprosy Teaching and Research Institute (C.L.T. & R.I.) Chengalpattu, took up studies on dapsone resistance in M. leprae from 1974. From 1978, the study was further strengthened by a project under THELEP (TDR) for eliciting information on the efficacy of certain drug regimens. The Thelep studies were to be conducted only on the dapsone sensitive untreated cases and, therefore, directed towards the detection of primary resistance, while the non-THELEP institutional studies were concentrated on secondary dapsone resistance problem. These two studies together detected 99 cases of dapsone resistance in the patients who attended CLTRI Hospital during 1974-81; 23 of them, were of primary origin, 16, 6 and 1 showing mild (RI), moderate (RII), and high (RIII) grades respectively. Of the remaining 76 cases of secondary resistance, 7 and 69 were of RII and RIII grades respectively. The need for vertical and horizontal monitoring of the drug resistance problem has been pointed out.</p>  a0254-9395