02207nas a2200385   4500000000100000008004100001260001300042653001500055653001000070653000900080653002800089653002500117653001000142653001200152653001800164653001100182653002500193653001100218653001200229653002600241653003500267653000900302653001600311100001500327700001600342700001500358700001600373700001300389245012600402856009000528300001100618490000700629520117100636022001401807       1975                            d  c1975 Dec10aAdolescent10aAdult10aAged10aAntibodies, Antinuclear10aAntibody Specificity10aChild10aDapsone10aEthnic Groups10aFemale10aHepatitis B Antigens10aHumans10aleprosy10aLymphocyte Activation10aLymphocyte Culture Test, Mixed10aMale10aMiddle Aged1 aNelson D S1 aPenrose J M1 aWaters M F1 aPearson J M1 aNelson M00aDepressive effect of serum from patients with leprosy on mixed lymphocyte reactions. Influence of anti-leprosy treatment.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1538440/pdf/clinexpimmunol00256-0015.pdf  a385-920 v223 a<p>Mixed leucocyte cultures, from two normal donors, were set up in media containing human serum from one of the following sources: (a) a pool of normal group AB donors; (b) Chinese, Malay or Indian patients with untreated leprosy; (c) the same patients after effective anti-leprosy treatment; (d) control Chinese, Malay or Indian subjects. Transformation was estimated by measuring the incorporation of tritiated thymidine in the last 24 hr of a 7-day culture period. Transformation was impaired in sera from treated lepromatous patients, but was less impaired  or not impaired at all in sera from treated lepromatous patients. The loss of depressive activity after treatment was more marked in Chinese and Indian than in Malay patients. Transformation was also impaired, though to a lesser extent, in sera from patients with untreated tuberculoid leprosy; it was still impaired in sera from treated tuberculoid patients. There was no evidence of specificity in impairment of mixed lymphocyte reactivity and lymphocytotoxic antibodies appeared to play no role. The incidences of hepatitis B antigen and antibody and of anti-nuclear factor were not notably high.</p>  a0009-9104