01686nas a2200289   4500000000100000008004100001260000900042653002600051653001000077653001800087653001100105653001200116653001600128653001400144653001200158100001200170700001300182700001600195700001300211700001100224700001600235245006100251300001100312490000700323520105200330022001401382       1992                            d  c199210aAcetylglucosaminidase10aAdult10aGlucuronidase10aHumans10aleprosy10aMiddle Aged10aMonocytes10aZymosan1 aKumar B1 aJaswal S1 aVaishnavi C1 aThakur M1 aKaur S1 aGanguly N K00aRelease of acid hydrolases in spectrum of human leprosy.  a405-110 v363 a<p>Release of acid hydrolases by blood monocytes (BM) of leprosy patients both before and after 6 months of chemotherapy was measured fluorimetrically. Monocyte cultures were set up for spontaneous as well as zymosan dependent enzyme release measured after 2 hrs and 24 hrs of culture. In the untreated multibacillary group (BL/LL) a significantly higher (P < 0.001) release of both B-glucuronidase (BG) and N-acetyl glucosaminidase (NAG) was observed compared to the paucibacillary group (BT/TT) and healthy controls. On comparing the BT/TT group with controls a significant decrease (P < 0.001) in zymosan dependent NAG release was observed in the former group at 2 hrs culture. After 6 months of antileprosy therapy, a significant decrease (P < 0.05) in BG release was observed from BM of multibacillary patients, whereas NAG activity increased significantly (P < 0.05) in the paucibacillary group compared to the controls. The results of the present study suggest that non-oxidative metabolic status of BM vary within the leprosy spectrum.</p>  a0022-1732