01880nas a2200301   4500000000100000008004100001260001300042653002900055653002400084653001100108653002200119653001200141653002600153653001600179653002500195653002500220100001200245700001400257700001600271700001300287700001500300245016200315856004100477300001000518490000700528520102900535022001401564       1992                            d  c1992 Dec10aAntigen-Antibody Complex10aAntigens, Bacterial10aHumans10aImmunosuppression10aleprosy10aLymphocyte Activation10aLymphocytes10aMycobacterium leprae10aPolyethylene Glycols1 aTyagi P1 aPatil S A1 aGirdhar B K1 aKatoch K1 aSengupta U00aSuppressive effect of circulating immune complexes from leprosy patients on the lymphocyte proliferation induced by M. leprae antigens in healthy responders.  uhttp://ila.ilsl.br/pdfs/v60n4a06.pdf  a562-90 v603 a<p>The effect of circulating immune complexes, isolated in the form of polyethylene glycol (PEG) precipitates from leprosy patients, on lymphocyte proliferation was studied. The results obtained showed that PEG precipitates obtained from the borderline lepromatous/lepromatous (BL/LL) types of leprosy patients and those undergoing erythema nodosum leprosum (ENL) had significant suppressive effects on the lymphocyte proliferation induced by Mycobacterium leprae antigens in healthy responders. The percent decreases in the mean values of delta cpm in the presence of PEG precipitates from the BL/LL and ENL groups were found to be 46.8 +/- 22.4 and 65.0 +/- 24.3, respectively. However, no significant suppressive effects (except for ENL PEG precipitates) of these PEG precipitates were observed on the lymphocyte proliferation induced by tuberculin (PPD). Further, PEG precipitates alone (in the absence of M. leprae antigen) from the BL/LL and ENL groups were found to have no effect on the lymphocyte proliferation.</p>  a0148-916X