01110nas a2200313   4500000000100000008004100001260001300042653001200055653003100067653003000098653003000128653001100158653002300169653001200192653000900204653001600213653001300229100001300242700001300255700001500268700001100283700001100294245007900305856004100384300001000425490000700435520034000442022001400782       2003                            d  c2003 Mar10aDapsone10aDrug Resistance, Bacterial10aDrug Resistance, Multiple10aDrug Therapy, Combination10aHumans10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aRifampin1 aNorman G1 aJoseph G1 aEbenezer G1 aRao SP1 aJob CK00aSecondary rifampin resistance following multi-drug therapy--a case report.  uhttp://ila.ilsl.br/pdfs/v71n1a04.pdf  a18-210 v713 a<p>This is the first report of secondary resistance to rifampin following MDT in a patient with prolonged, but irregular treatment. Repeated mouse foot-pad studies demonstrated resistance to dapsone after several years of monotherapy, and following subsequent MDT the studies demonstrated the development of resistance to rifampin.</p>  a0148-916X