00888nas a2200085   4500000000100000008004100001100001600042245009700058520064700155       2019                            d1 aFerrari CKB00aOxidative stress and antioxidant supplementation on immunity in Hansen’s disease (leprosy)3 a<p>Hanseniasis comprises one of the main causes of physical disabilities due to its potential to strike neural lesions, foot deformities, amputations, and mutilations. Since innate response is important in hanseniasis, this work reviewed and updated the role of reactive oxygen/nitrogen species in different clinical forms of hanseniasis, as well as their role in different phagocyte free radicals’ generator systems (NADPH-oxidase, mitochondrial pathways, myeloperoxidase, extracellular traps, iNOS). Since hanseniasis can induce antioxidant depletion, possible benefits of antioxidant nutritional supplementation are also discussed.</p>