01267nas a2200241   4500000000100000008004100001260001300042653003100055653002700086653001100113653002000124653001100144653001200155653000900167100001500176700001400191245003700205856004100242300001000283490000700293520071100300022001401011       2003                            d  c2003 Jun10aChromosomes, Human, Pair 610aDisease Susceptibility10aFemale10aGenetic Linkage10aHumans10aleprosy10aMale1 aBuschman E1 aSkamene E00aLeprosy susceptibility revealed.  uhttp://ila.ilsl.br/pdfs/v71n2a05.pdf  a115-80 v713 a<p>In order for these findings to have practical significance in terms of leprosy control and prevention, it will be necessary to extend the linkage of chromosome 6q25 to another region endemic for leprosy. Replicative findings would likely mean that the chromosome 6q25 susceptibility gene is a variant of a common gene that promotes susceptibility to infection per se. Identification of the gene variant will hopefully reveal insight about transmission and disease incidence--the longstanding enigmas of leprosy. Whether a more effective, universal MDT treatment or another type of prevention (either vaccine or environmental) could be based on this knowledge, is an exciting prospect to contemplate.</p>  a0148-916X