01273nas a2200205   4500000000100000008004100001100001100042700001600053700001200069700001200081700001300093700001300106700001300119700001600132245011400148300001200262490000600274520077300280022001401053       2019                            d1 aKama G1 aHuang G K L1 aTaune M1 aArura R1 aMorris L1 aKombuk B1 aMarome A1 aO'Brien D P00aTuberculosis treatment unmasking leprosy: management of drug-resistant tuberculosis and leprosy co-infection.  aS83-S850 v93 a<p>Co-infection with tuberculosis (TB) and leprosy is thought to occur infrequently, but has been reported in settings highly endemic for both infectious diseases. We report for the first time a case where treatment for multidrug-resistant TB (MDR-TB) led to the 'unmasking' of clinically silent leprosy through the precipitation of a type-1 immunological reaction. Current treatment regimens for MDR-TB may contain a number of drugs, such as levo-floxacin and clofazimine, which also have activity against M. leprae. A treatment regimen containing drugs active against both mycobacterial species may be used to achieve cure. Individual considerations on drug-drug interactions, potential additive toxicities and other comorbidities should be taken into account.</p>
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