01700nas a2200373   4500000000100000008004100001260001300042653002600055653002400081653003800105653001300143653002900156653001600185653001100201653002100212653002100233653001200254653003100266653003000297653003200327653002000359100001300379700001300392700001400405700001400419700001100433700001400444245015500458856004100613300001100654490000700665520064000672022001401312       1992                            d  c1992 Sep10aAntibodies, Bacterial10aAntigens, Bacterial10aEnzyme-Linked Immunosorbent Assay10aEpitopes10aFalse Negative Reactions10aGlycolipids10aHumans10aImmunoglobulin G10aImmunoglobulin M10aleprosy10aMycobacterium tuberculosis10aPredictive Value of Tests10aSensitivity and Specificity10aSerologic Tests1 aLaszlo A1 aCruaud P1 aGoren M B1 aHandzel V1 aPapa F1 aDavid H L00aComparison of bis-di-octadecylamide of trehalose dicarboxylic acid (BDA.TDA) with glycolipid SL-IV as ELISA antigens for the serodiagnosis of leprosy.  uhttp://ila.ilsl.br/pdfs/v60n3a05.pdf  a376-810 v603 a<p>Two glycolipids--one synthetic and non-natural (BDA.TDA), the other natural and Mycobacterium tuberculosis species-specific (SL-IV)--were tested to determine their serological activity in sera obtained from leprosy patients, and to determine their discriminating ability in the detection of disease. The ELISA results obtained in the IgG antibody class show that both were useful substances capable of detecting multibacillary and paucibacillary disease in about 2 out of 3 leprosy patients. When these antigens were tested in parallel, the sensitivity of the ELISA test was increased by 10% without a decrease in specificity.</p>
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