01916nas a2200229   4500000000100000008004100001100001600042700001600058700001700074700001600091700001400107700001800121700001700139700001300156700001200169700001300181245021500194856007000409490000700479520118600486022001401672       2019                            d1 aTrianita MN1 aRumondor BB1 aPrakoeswa AC1 aIswahyudi I1 aAdriaty D1 aKusumaputra B1 aListiawan MY1 aAgusni I1 aIzumi S1 aDuthie M00aA simpler diagnostic method using blood collection on filter paper to determine anti-natural octyl disaccharide-leprosy infectious disease research institute diagnostic in household contacts of leprosy patients  uhttps://www.pagepress.org/journals/index.php/dr/article/view/80480 v113 a<p>The high prevalence among children shows continued transmission from adult and lack of disease control by the health system. Detection of anti-NDO-LID-1 has been known to be more effective to predict the development of leprosy in household contacts than just detecting PGL-1 or LID- 1 alone. However, serodiagnosis is not available in poorer-settings area and the procedure (venepuncture) is still inconvenient to some people. These problems can be solved by using finger-prick blood sample on filter paper. This study aims to prove the effectiveness of using capillary blood samples on filter paper to detect the positivity of Ig G antibody against NDO-LID-1 antigen in asymptomatic household contacts. Seventeen samples of capillary blood on filter paper and sera were tested for IgG anti-NDO-LID-1 using ELISA. There was no significant difference between IgG level from filter paper and serum (p=0.754) and there was also a strong positive correlation (R=0.906) between the two procedures. These findings show that the use of filter paper and NDO-LID-1 is worthy of further investigations, especially for those with lower bacillary load or contacts of leprosy patients.</p>
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