01471nas a2200133   4500000000100000008004100001100001600042700001400058245012700072856007000199490000700269520104700276022001401323       2019                            d1 aWidiatma RR1 aSukanto H00aDiffuse lepromatous leprosy caused by dual infection of mycobacterium leprae and mycobacterium lepromatosis: A case report  uhttps://www.pagepress.org/journals/index.php/dr/article/view/80940 v113 a<p><em>M. lepromatosis</em> is the dominant cause of leprosy in Mexico and it co-exists with <em>M. leprae</em> in endemic areas as the once elusive second cause of leprosy. A 41-year-old Madurese woman came with multiple ulcer on her legs, hands and buttock. The ulcers were described as wide and deep, covered with blackish crusts and some exudative area with irregular edges. On face, there were difusse infiltration, madarosis and saddle nose. Histopathology showed thinning of epidermis with a lot of foam cells containing BTA, including endotel and perivascular tissues. Nested PCR examination with LERF2-MLER4 primers for detecting <em>M. leprae</em> showed a positive result. Advanced PCR examination using LPMF2-MLER4 primers for detecting <em>M. lepromatosis</em> also showed a positive result. Based on the clinical, hystopathological results and PCR examination, it was consistent with diffuse lepromatous leprosy. <em>M. lepromatosis</em> mainly causes lepromatous leprosy and also specifically diffuse lepromatous leprosy.</p>
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