02050nas a2200421   4500000000100000008004100001260001300042653001000055653001000065653001600075653001200091653003000103653001100133653001100144653002300155653001200178653002400190653002500214653000900239653001600248653002600264653001300290653000900303100001100312700001100323700001400334700001300348700001400361700001400375700001000389700001100399245011800410856004100528300001000569490000700579520102800586022001401614       1989                            d  c1989 Sep10aAdult10aChina10aClofazimine10aDapsone10aDrug Therapy, Combination10aFemale10aHumans10aLeprostatic Agents10aleprosy10aLeprosy, Borderline10aLeprosy, lepromatous10aMale10aMiddle Aged10aRetrospective Studies10aRifampin10aSkin1 aLi H Y1 aYu X L1 aZhang M S1 aDuan C X1 aHuang W B1 aZhang S B1 aZhu K1 aMa J F00aShort-term multidrug therapy in multibacillary leprosy--review of 80 cases in two provinces of China (1983-1988).  uhttp://ila.ilsl.br/pdfs/v57n3a04.pdf  a622-70 v573 a<p>Thirty-three active multibacillary patients from nine counties of Weifang Prefecture, Shandong Province, and 47 active cases from Menla County, Yunnan Province, People's Republic of China, were treated with 24 and 27 months of multidrug therapy (MDT), respectively, in 1983. Clinical assessments, smears, and histopathologic examinations were carried out independently by study teams from the Institutes of Dermatology of these two provinces. Reexaminations at 12-14 months and at termination of therapy showed marked improvement, and there was continued improvement at 12-18 and 33 months on follow up. Conversion of the bacterial index to negativity was 0/33, 5/47 for the patients from Shandong and Yunnan provinces, respectively, at the end of MDT and 2/33 at 12 months' and 17/47 at 18 months' follow up, which increased to 21/33 and 26/44 at 33 months' follow up. Regression of specific infiltration was about 21%-100% after 24-27 months of MDT; further regression to 95%-100% occurred at 33 months' follow up.</p>  a0148-916X