02310nas a2200397   4500000000100000008004100001260001300042653001500055653001000070653001600080653001200096653003300108653003000141653001100171653002200182653001100204653002300215653001200238653000900250653001300259653000900272653002200281653003000303100001200333700001600345700001600361700001300377700001000390245018600400856005100586300001000637490000700647050003200654520121200686022001401898       2003                            d  c2003 Jun10aAcedapsone10aAdult10aClofazimine10aDapsone10aDrug Administration Schedule10aDrug Therapy, Combination10aFemale10aFollow-Up Studies10aHumans10aLeprostatic Agents10aleprosy10aMale10aRifampin10aSkin10aTreatment Outcome10aWorld Health Organization1 aShaw IN1 aChristian M1 aJesudasan K1 aKurian N1 aRao G00aEffectiveness of multidrug therapy in multibacillary leprosy: a long-term follow-up of 34 multibacillary leprosy patients treated with multidrug regimens till skin smear negativity.  uhttps://leprosyreview.org/article/74/2/14-1147  a141-70 v74  aInfolep Library - available3 a<p>The World Health Organization (WHO) Field Trials of multidrug therapy (MDT) started at Schieffelin Leprosy Research and Training Centre (SLR & IC), Karigiri, India in December 1981. The patients were treated with two MDT regimens. The first (regimen A) consisted of 600mg rifampicin and 300mg of clofazimine given under supervision on 2 consecutive days monthly, 225mg injection of acedapsone bimonthly and dapsone 100mg daily. The second regimen (regimen B) was the conventional MDT (WHO/MDT), rifampicin 600mg and clofazimine 300mg supervised once a month, dapsone 100mg and clofazimine 50mg daily, unsupervised. Both the regimens were administered for a minimum period of 2 years or until skin smear negativity, whichever occurred later. Thirty-four newly detected previously untreated MB patients, 16 of whom received regimen A and 18 regimen B, were reassessed. Both regimens were well accepted and well tolerated by the patients. Clofazimine discolouration was the only adverse effect of MDT seen in these patients. After completion of treatment with MDT, the patients were followed up for a total duration of 466 person-years with a mean of 13.7 +/- 1.4 years per patient. No relapse was seen.</p>  a0305-7518