01590nas a2200265   4500000000100000008004100001260001300042653001200055653001100067653001200078653000900090653002100099653001900120653001800139653002000157653002500177653001800202653002200220100001600242245013800258300001100396490000800407520089500415022001401310       1975                            d  c1975 Sep10aAnimals10aHumans10aleprosy10aMice10aMice, Inbred CBA10aMotor Endplate10aMotor Neurons10aMuscle Spindles10aMycobacterium leprae10aNerve Endings10aNeurons, Afferent1 aEdwards R P00aAn ultrastructural study of neuromuscular spindles in normal mice: with reference to mice and man infected with Mycobacterium leprae.  a149-680 v1203 a<p>Mycobacterium leprae have been found within muscle spindles in mice, using electron microscopy, and in man, using light microscopy. Their mode of entry clearly is important. It may be via capsular cells, capillaries or nerves. For this reason muscle spindles from normal mice were studied by electron microscopy with special reference to the capsule and the relationship of it with capillaries and nerves, as well as details of the intrafusal fibres and capsular space. A fenestrated capillary was found between the capsular cell layers and outside the capsule in one spindle and in another spindle both a fenestrated and a continuous type of a capillary were found between the capsular cells; this may be of interest for pharmacological studies. However, the muscle spindles of the mouse were in the main similar to muscle spindles studied by other workers in man and other mammals.</p>  a0021-8782