01728nas a2200181   4500000000100000008004100001100001600042700001500058700001500073700002000088700001400108245007400122856008400196300000800280490000700288520123700295022001401532       2018                            d1 aCortela DCB1 aNogueira M1 aPereira AC1 aSouza Junior AL1 aIgnotti E00aInflammatory cytokines in leprosy reactions and periodontal diseases.  uhttp://www.scielo.br/pdf/rimtsp/v60/1678-9946-rimtsp-60-S1678-9946201860068.pdf  ae680 v603 a<p>The inflammatory cytokines involved in the immune response to chronic periodontal disease (CPD) in the context of leprosy reactions (LR) were analyzed in 57 new cases of multibacillary leprosy (MBL). They were stratified by the presence of CPD and LR. Messenger RNA (mRNA) expression of inflammatory mediators was determined by qRT-PCR using skin biopsy and by ELISA using serum samples, maintaining 5% of significance level in ANOVA and correlation analyses. Twenty-three (40.4%) patients presented the first LR, whereas 22 (45.0%) patients presented CPD. IL-4 and IL-6 serum levels were significantly lower in patients with CPD and LR than in patients without CPD but with LR; IFN-γ serum levels were higher in patients with CPD and LR than in patients with no CPD and no LR; IL-4 serum levels were negatively correlated with TNF-α gene expression, while IL-6 serum levels were positively correlated with IFN-γ gene expression, in the skin of subjects with CPD and LR. The presence of DPC in individuals with LR immunoregulated IL-6, IFN-γ, and IL-4 concentrations. The presence of DPC decreased serum levels of IL-6 and IL-4 in reactional individuals. CPD concomitant to LR resulted in increased IFN-γ serum levels.</p>
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