02620nas a2200217   4500000000100000008004100001653001200042653002400054653002200078653002500100100001100125700001200136700001300148700001300161700001200174245006800186856006300254300000800317490000600325520207100331       2018                            d10aleprosy10aTuberculoid leprosy10aMast cell profile10aLaperomatous disease1 aMohit 1 aDixit S1 aSharma R1 aSharma P1 aKumar P00aEvaluation of Mast Cell Profile in the Skin Lesions of Leprosy.  uhttp://www.aimdrjournal.com/pdf/vol4Issue6/PT2_OA_V4N6.pdf  a5-80 v43 a<p><strong>Background: </strong>Aim of the present study was to evaluate the role of Mast cells in the Histo-Pathogenesis of Leprosy by assessing incidence of various Histo-Pathological types of Leprosy, Correlating of Mast cell profile (Mast cell Density &amp; Morphology) in different Histological types of Leprosy lesions, by correlating with Reactional &amp; Non-Reactional groups of Leprosy cases and by correlation of Mast cell profile in doubtful cases as in Indeterminate type. Lepromatous Leprosy was observed in higher age group as compared to Tuberculoid leprosy. Mast Cell Density was found increasing from Polar Tuberculoid to Polar Lepromatous spectrum of disease. In every type of Leprosy, mast Cell Density was reduced significantly in the Reactional Group as compared to Non-Reactional Group. The aim of the present study was to evaluate the role of Mast cells in the Histo-Pathogenesis of Leprosy by assessing incidence of various Histo-Pathological types of Leprosy. <strong>Methods: </strong>A cross sectional, observational study was conducted among 200.Correlation of mast cell profile (Mast cell Density &amp; Morphology) in different Histological types of Leprosy lesions was done, by correlating with Reactional &amp; Non-Reactional groups of Leprosy cases and by correlation of Mast cell profile in doubtful cases as in Indeterminate type. Lepromatous Leprosy was observed in higher age group as compared to Tuberculoid leprosy. <strong>Results: </strong>Mast Cell Density was found Increasing from Polar Tuberculoid to Polar Lepromatous spectrum of disease. In every type of Leprosy, mast Cell Density was reduced significantly in the Reactional Group as compared to Non-Reactional Group. <strong>Conclusion: </strong>Larger such studies of Leprosy employing special staining methods viz. pH dependent Toluidine Blue staining, studies employing Immuno-Fluorescence on Tissue biopsy specimens, as well as studies on experimental animals, to help us achieve a better understanding of the pathogenesis, outcome and prognosis of Leprosy.</p>