01410nas a2200145   4500000000100000008004100001100001200042700001200054245014500066856009800211300001200309490000700321520092200328022001401250       2018                            d1 aPawar M1 aSingh M00aSparfloxacin-induced photo-onycholysis and photosensitivity characteristically sparing lepromatous skin lesions: an interesting observation.  uhttps://s3-eu-west-1.amazonaws.com/thejournalhub/10.15570/actaapa.2018.30/actaapa.2018.30.pdf  a149-1510 v273 a<p>Sparfloxacin is an antibiotic in the quinolone group of antibacterial agents, which often induce photosensitive skin reactions, more often phototoxic reactions than photoallergic ones, and sometimes associated photo-onycholysis. We present a case of phototoxic dermatitis with photo-onycholysis in a 38-year-old man probably induced by sparfloxacin, which was prescribed to him along with rifampicin and clofazimine because he was suffering from borderline lepromatous leprosy. He developed exaggerated sunburn-like eruptions mainly on sun-exposed sites along with painful onycholysis of the fingernails. Interestingly, the hypopigmented patches of leprosy were spared, which is a very rare phenomenon. Withdrawal of sparfloxacin along with administration of systemic steroids and other supportive measures helped heal the skin eruptions with hyperpigmentation, but the photo-onycholysis was slow to resolve.</p>
  a1581-2979