01240nas a2200337 4500000000100000008004100001260001300042653001200055653002300067653002300090653001100113653001200124653000900136653002400145653002400169653002500193653001600218100001500234700002100249700001600270700001400286700001000300700001100310700001500321245011400336856006900450300001100519490000700530520035100537022001400888 2003 d c2003 Mar10aAnimals10aBacterial Vaccines10aCell Wall Skeleton10aFemale10aleprosy10aMice10aMice, Inbred BALB C10aMycobacterium bovis10aMycobacterium leprae10aVaccination1 aNgamying M1 aSawanpanyalert P1 aButraporn R1 aNikasri J1 aCho S1 aLevy L1 aBrennan PJ00aEffect of vaccination with refined components of the organism on infection of mice with Mycobacterium leprae. uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC148868/pdf/1297.pdf a1596-80 v713 a
Only native products of Mycobacterium leprae, whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton-the mycolyl-arabinogalactan-peptidoglycan complex-devoid of proteins is not protective.
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