02216nas a2200421   4500000000100000008004100001260001700042653001500059653001000074653001000084653002100094653001600115653001200131653003000143653001100173653001100184653001100195653002000206653002300226653001200249653000900261653001600270653002300286653002100309653002600330653001300356100001600369700001300385700001600398700001700414700001200431245014400443856005100587300001100638490000700649520112400656022001401780       2002                            d  c2002 Sep-Oct10aAdolescent10aAdult10aChild10aChild, Preschool10aClofazimine10aDapsone10aDrug Therapy, Combination10aFemale10aHumans10aInfant10aInfant, Newborn10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aPatient Compliance10aPatient Dropouts10aRetrospective Studies10aRifampin1 aGoulart IMB1 aArbex GL1 aCarneiro MH1 aRodrigues MS1 aGadia R00a[Adverse effects of multidrug therapy in leprosy patients: a five-year survey at a Health Center of the Federal University of Uberlândia].  uhttp://www.scielo.br/pdf/rsbmt/v35n5/13162.pdf  a453-600 v353 a<p>The introduction of multidrug therapy (WHO/MDT)-composed by the drugs dapsone, clofazimine and rifampicin has enabled the cure of Hansen's disease, however, the adverse effects of these drugs were not given priority by the health team. Aiming to determine MDT's adverse effects' magnitude and relate them to the non-adhesion of patients to the treatment, a study of 187 charts of patients treated with MDT from January of 1995 to May 2000, was carried out at a Health Center of the Federal University of Uberlândia. Side effects were recorded in 71 patients' charts. Among the 113 side effects found, 80 (70.7%) were related to dapsone, 7 (6.2%) were caused by rifampicin and 26 (20.5%) were attributed to clofazimine. These effects induced 28 (14.9%), patients to change the therapeutic scheme, representing 39.4% from the 71 patients with adverse effects. Throughout this study, the importance is discussed of considering MDT's adverse effects when training the health team to heighten the patient's adhesion to the treatment and thereby collaborating to eliminate Hansen's disease as a public health problem.</p>  a0037-8682