01790nas a2200265   4500000000100000008004100001653001200042653001000054653002000064653002500084653002300109100001300132700001700145700001300162700001200175700001200187700002500199700001500224700001700239245015200256300000800408490000800416520108600424022001401510       2018                            d10aleprosy10aCD20710aDendritic Cells10aImmunohistochemistry10aImmunopathogenesis1 aHirai KE1 aMota Silva L1 aSousa JR1 aSouza J1 aDias LB1 aOliveira Carneiro FR1 aAarão TLS1 aQuaresma JAS00aLangerin (CD207)-positive cells in leprosy: Possible implications for pathogenesis of the disease with special emphasis on dermal immunoreactivity.  a1-40 v1243 a<p>Leprosy is a disease caused by Mycobacterium leprae, which is characterized by two distinct poles, the tuberculoid pole and the lepromatous pole, depending on the immune response to the bacillus. Langerin-positive cells are dendritic cells that appear to play an essential role in the development of the disease. These cells are specialized in the processing and presentation of antigens, exerting an important function in the activation of the immune system. To evaluate the expression of langerin-positive cells (CD207+) in skin lesion fragments of patients with a diagnosis of M. leprae infection and to associate the expression of these cells with the polar forms of the disease. Langerin-positive cells were detected in larger numbers in lesions of patients with the tuberculoid form compared to those with the lepromatous form. The presence of a larger number of these cells in patients with the tuberculoid form suggests an important participation of langerin-positive cells, capturing antigens and favoring an effective immune response to infection with M. leprae.</p>
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