01648nas a2200193   4500000000100000008004100001653001200042653003500054653001600089100001000105700001000115700001100125700001100136245007300147300001100220490000700231520120200238022001401440       2018                            d10aleprosy10aBorderline tuberculoid leprosy10aSarcoidosis1 aLiu J1 aWen Y1 aXing Y1 aWang S00aBorderline tuberculoid leprosy mimicking sarcoidosis: A case report.  ae116160 v973 a<p><strong>INTRODUCTION: </strong>Leprosy is a chronic infectious granulomas disease caused by Mycobacterium leprae that can manifest as a wide variety of immunological and clinical features.</p>

<p><strong>CASE SUMMARY: </strong>Here, we describe the case of a woman with clinical characteristics of borderline tuberculoid (BT) leprosy that manifested as 3 asymmetric skin lesions involving her hip and lower limbs. This unusual presentation was initially misdiagnosed as sarcoidosis because noncaseating granulomas are a histopathological feature of both diseases. Differentiation and the diagnosis of BT leprosy was achieved using real-time polymerase chain reaction (PCR) to amplify an M leprae specific DNA sequence and to detect serum antibodies specific to M leprae antigens. Accordingly, a 6-month course of multidrug therapy led to a marked improvement in the skin lesions.</p>

<p><strong>CONCLUSION: </strong>The use of auxiliary tests including real-time PCR to amplify an M leprae-specific DNA sequence, enzyme-linked immunosorbent assay, and dipstick detection of serum antibodies specific to M leprae antigens are good methods to obtain a correct diagnosis of BT leprosy.</p>
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