01947nas a2200397   4500000000100000008004100001260001300042653001500055653001000070653000900080653001000089653001600099653001200115653003000127653001100157653001100168653001200179653000900191653002000200653001600220653001500236653002600251653001300277653001000290653002200300653002200322100001300344700001200357700001600369245005700385856015100442300001000593490000700603520092500610022001401535       2003                            d  c2003 Feb10aAdolescent10aAdult10aAged10aChild10aClofazimine10aDapsone10aDrug Therapy, Combination10aFemale10aHumans10aleprosy10aMale10aMedical Records10aMiddle Aged10aRecurrence10aRetrospective Studies10aRifampin10aTexas10aTreatment Failure10aTreatment Refusal1 aMurray C1 aJoyce P1 aLongfield R00aShort report: Treatment failure in Hansen's disease.  uhttp://www.ajtmh.org/docserver/fulltext/14761645/68/2/0680233.pdf?expires=1504774416&id=id&accname=guest&checksum=243503B106BF9FA41229F34D92BB0C54  a233-40 v683 a<p>Areas of low endemicity of Hansen's disease, such as Texas, California, and Hawaii, exist due to immigration and rare autochthonous infections. Managing this disease in these areas of low endemicity is difficult, especially in observing for relapse. The accurate diagnosis of relapse is imperative so that appropriate therapy can be promptly reinstituted and unnecessary treatment can be avoided. To assess treatment failures in an area of low endemicity, we retrospectively evaluated 113 patients with Hansen's disease treated in southern Texas. Of 57 patients who completed therapy, 11 were later restarted on medications for this disease for presumed relapse. However, nine of the 11 were found not to have true relapses of Hansen's disease. The accurate diagnosis of relapse of this disease is essential not only in the individual patient but also for prospective treatment trials to establish best practices.</p>  a0002-9637