02421nas a2200445   4500000000100000008004100001653001500042653001000057653002100067653000900088653002200097653001000119653001000129653002100139653001100160653001100171653001400182653001100196653000900207653001600216653004500232653002700277653001800304653002100322653002900343100001500372700001300387700001400400700001300414700001500427700001400442700001400456700001500470245008700485856007700572300001300649490000600662520129300668022001401961       2004                            d10aAdolescent10aAdult10aAge Distribution10aAged10aAged, 80 and over10aBenin10aChild10aChild, Preschool10aFemale10aHumans10aIncidence10aInfant10aMale10aMiddle Aged10aMycobacterium Infections, Nontuberculous10aMycobacterium ulcerans10aOsteomyelitis10aSex Distribution10aSkin Diseases, Bacterial1 aDebacker M1 aAguiar J1 aSteunou C1 aZinsou C1 aMeyers W M1 aScott J T1 aDramaix M1 aPortaels F00aMycobacterium ulcerans disease: role of age and gender in incidence and morbidity.  uhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-3156.2004.01339.x  a1297-3040 v93 a<p>During the 5-year period, 1997-2001, 1700 patients with a clinical diagnosis of Mycobacterium ulcerans disease [Buruli ulcer (BU)] were treated at the Centre Sanitaire et Nutritionnel Gbemoten, Zagnanado, Benin. The patients lived in the four regions of southern Benin: Atlantique, Mono, Oueme and Zou, with the largest number coming from the Zou Region where the centre is located. The median age of BU patients was 15 years (q1=7, q3=30). Lower limbs are involved 3.2 times more frequently than upper limbs in older patients and younger patients have the highest prevalence of multiple lesions. The latter are frequently associated with bone lesions. Specific detection rates for age and gender showed a distribution with maximum peaks in the 10-14 years group and among adults between 75 and 79 years. Over 59 years, males are more at risk of developing M. ulcerans disease than females. Children under 15 years represent the largest part of the BU disease burden and of the general population. The highest detection rates (per 100,000 population) were in the 75-79-year-old patients. The most likely explanation of this was reactivation of disease from a latent infection of M. ulcerans. Educational programmes should target especially these two groups of population at risk.</p>
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