01913nas a2200229   4500000000100000008004100001653001200042653004200054653002700096653003400123100001100157700001500168700001500183700001100198700001300209245009200222856007300314300001000387490000700397520126500404022001401669       2018                            d10aleprosy10aEnzymatic oxidative stress indicators10aOxidative stress index10aReactive oxygen species (ROS)1 aRaka I1 aRastogi MK1 aGahalaut P1 aKaur J1 aMishra N00aEnzymatic Oxidative Stress Indicators and Oxidative Stress Index in Patients of Leprosy  uhttps://www.nepjol.info/index.php/NJDVL/article/download/19402/15948  a35-400 v163 a<p><strong>Introduction: </strong>Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Oxidative stress caused by Reactive oxygen species (ROS) plays a crucial role in the pathogenesisis of leprosy.</p>

<p><strong>Objective: </strong>To measure the enzymatic oxidative stress indicators and oxidative stress index in patients of leprosy and compare them with healthy age &amp; sex matched controls.</p>

<p><strong>Materials and Methods: </strong>In this prospective study 30 untreated leprosy patients were included in the study and matched with 60 healthy controls. Biochemistry estimation was done with blood samples and MDA (lipid peroxidation), Nitric oxide (NO), (SOD) Superoxide dismutase (antioxidant enzyme), total oxidant status (TOS), total antioxidant status(TAS) and oxidative stress index (OSI) were estimated.</p>

<p><strong>Results: </strong>Highly significant rise (p&lt;0.0001) in serum MDA, NO, TOS and OSI was seen in leprosy patients when compared with controls with highly significant decline in SOD and TAS.</p>

<p><strong>Conclusion: </strong>The study confirms the oxidative stress in leprosy and suggests antioxidant therapy may be used as an adjuvant in the treatment of leprosy along with MDT.</p>
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