01608nas a2200241   4500000000100000008004100001260001700042653001000059653001100069653001100080653001300091653001200104653000900116100001400125700001700139700001600156700001800172245007100190300000900261490000600270520107600276022001401352       1975                            d  c1975 Sep-Dec10aAdult10aFemale10aHumans10aImmunity10aleprosy10aMale1 aFlies E L1 aBachmann A E1 aC Sasiain M1 aRuibal Ares B00a[Immunological examination of patients with undetermined leprosy].  a81-50 v73 a<p>The immunological competence of eleven patients with undetermined leprosy was compared with that of ten normal volunteers of the same age and sex distribution; these controls have not had previous contact with leprosy. The following parameters were studied in peripheral blood cells: 1) percentage of lymphocyte bearing surface immunoglobulins, as revealed by immunofluorescence; 2) percentage of lymphocyte bearing complement receptors, as studied by antibody and complement coated erithrocyte rosetting; 3) percentage of T cells, as revealed by spontaneous sheep erithrocyte rosettes; 4) blastogenic and mytogenic response of cultured lymphocytes to PHA and 5) cell migration inhibition test using lepromine (80 x 10(6) bacilli/ml) as antigen. Skin reactions to lepromine were also assayed. In the six lepromine-positive patients with undetermined leprosy, no major immunological alterations could be detected. On the contrary, the five lepromine-negative patients showed important alterations which could well be considered as precursors of lepromatous leprosy.</p>  a0325-1713