01417nas a2200277   4500000000100000008004100001260001700042653002600059653001300085653001100098653002100109653001200130653002600142653002500168653002200193100001200215700001500227700001200242700001500254245003400269856004100303300001100344490000700355520076300362022001401125       1975                            d  c1975 Oct-Dec10aAdenosine Diphosphate10aCollagen10aHumans10aImmunoglobulin M10aleprosy10aPlatelet Adhesiveness10aPlatelet Aggregation10aPlatelet Factor 31 aGupta M1 aBhargava M1 aKumar S1 aMittal M M00aPlatelet function in leprosy.  uhttp://ila.ilsl.br/pdfs/v43n4a05.pdf  a327-320 v433 a<p>In a group of 50 leprosy patients, platelet function tests were found to be abnormal in 44. More than half the patients showed significant impairment in platelet adhesiveness and aggregation to collagen which correlated best with increase in serum IgM levels. ADP-induced aggregation of platelets was not a major defect and Pf-3 availability was reduced only in a fourth of the patients. In vitro incubation of collagen with plasma from leprosy patients significantly reduced its ability to clump normal platelets. This appears to be the first report of defective platelet function in leprosy, and it is thought that such changes may in part be due to increased IgM globulins in the blood and/or to alterations in the collagen brought about thereby.</p>
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