02079nas a2200421   4500000000100000008004100001260001300042653001000055653001200065653001600077653001200093653004100105653001100146653001100157653001000168653002300178653001200201653000900213653000900222653001600231653002500247653002600272100001200298700001900310700001500329700001600344700001400360700002100374700001400395700001600409245013000425856005100555300001100606490000700617050003200624520098700656022001401643       2002                            d  c2002 Sep10aAdult10aAnimals10aClofazimine10aDapsone10aDrug Resistance, Multiple, Bacterial10aFemale10aHumans10aIndia10aLeprostatic Agents10aleprosy10aMale10aMice10aMiddle Aged10aMycobacterium leprae10aRetrospective Studies1 aSekar B1 aElangeswaran N1 aJayarama E1 aRajendran M1 aKumar S S1 aVijayaraghavan R1 aAnandan D1 aArunagiri K00aDrug susceptibility of Mycobacterium leprae: a retrospective analysis of mouse footpad inoculation results from 1983 to 1997.  uhttps://leprosyreview.org/article/73/3/23-9244  a239-440 v73  aInfolep Library - available3 a<p>We analysed the results of mouse foot pad (MFP) tests performed between 1983 and 1997 in our laboratory for the cases referred with clinical suspicion of relapse/drug resistance. A total of 214 cases, with clinical suspicion of relapse/drug resistance were investigated for susceptibility to the drugs of MDT by MFP inoculation. Among 96 inoculations that showed conclusive results, 81 (84%) were fully sensitive to dapsone, suggesting that most of the clinically suspected relapse is due to drug susceptible Mycobacterium leprae. Of the remaining 15 strains (16%) found resistant to dapsone, 13 (87%) were of high grade resistance and one strain each of intermediate grade and low grade dapsone resistance, suggesting that most of the dapsone resistance is secondary in nature. No case of rifampicin resistance was found. Only one case of combined dapsone and unconfirmed clofazimine resistance was found. No other combined multidrug resistance was observed in our analysis.</p>  a0305-7518