01420nas a2200301   4500000000100000008004100001260001300042653001200055653001600067653003300083653003000116653002200146653001100168653002300179653001200202653001400214653001500228653001300243100001300256700001500269245010500284856005100389300001000440490000700450050003200457520061500489022001401104       2002                            d  c2002 Sep10aBelgium10aClofazimine10aDrug Administration Schedule10aDrug Therapy, Combination10aFollow-Up Studies10aHumans10aLeprostatic Agents10aleprosy10aOfloxacin10aRecurrence10aRifampin1 aPattyn S1 aGrillone S00aRelapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy.  uhttps://leprosyreview.org/article/73/3/24-5247  a245-70 v73  aInfolep Library - available3 a<p>Between 1989 and 1993, 136 multibacillary leprosy patients received a 6-week treatment regimen consisting of daily rifampicin 600 mg, ofloxacin 400 mg, clofazimine 100 mg and a weekly dose of 100 mg minocycline. A previous analysis after a mean follow-up of 4-7 years revealed a relapse rate of 2%, involving six late (after more than 5 years of follow-up) relapses. During the following years, 12 more relapses appeared during years 8-9 of follow-up. A mean follow-up period of 5 years is insufficient to evaluate treatment regimens in multibacillary leprosy. The present regimen cannot be recommended.</p>  a0305-7518