02375nas a2200229   4500000000100000008004100001653001200042653003500054653001000089100001700099700001300116700001300129700001200142700001200154700002500166700001500191700001300206700001700219245009400236520180100330022001402131       2017                            d10aleprosy10aEndothelial adhesion molecules10aNFκB1 aMota Silva L1 aHirai KE1 aSousa JR1 aSouza J1 aDias LB1 aOliveira Carneiro FR1 aAarão TLS1 aFuzii HT1 aQuaresma JAS00aNFκB transcription factor (p65) immunohistochemistry in leprosy dermal microvasculature.3 a<p>Leprosy caused by Mycobacterium leprae is characterized by a spectrum of clinical manifestations that are determined by the predominant immunological profile of the host. The recruitment of leukocytes to the sites of injury can influence the development of these profiles. Cell adhesion molecules such as ICAM-1, VCAM-1 and CD62E participate in this process and their expression is regulated by transcriptions factors such as NFκB. To correlate the expression of cell adhesion molecules and NFκB (p65) in leprosy lesions, 30 skin biopsies of patients with leprosy [16 with the tuberculoid (TT) or borderline tuberculoid (BT) forms and 14 with the lepromatous (LL) or borderline lepromatous (BL) forms] were analyzed by immunohistochemistry. A larger mean number of cells expressing VCAM-1 (BT/TT: 18.28&nbsp;±&nbsp;1.4; BL/LL: 10.67&nbsp;±&nbsp;1.2; p&nbsp;=&nbsp;0.0002), ICAM-1 (BT/TT: 9.92&nbsp;±&nbsp;1.1; BL/LL: 5.87&nbsp;±&nbsp;1.0; p&nbsp;=&nbsp;0.0084) and CD62E (BT/TT: 13.0&nbsp;±&nbsp;1.5; BL/LL: 2.58&nbsp;±&nbsp;0.3; p&nbsp;=&nbsp;0.0001) were observed in BT and TT lesions. The mean number of cells expressing NFκB was similar in the two clinical forms (BT/TT: 2.21&nbsp;±&nbsp;2.7; BL/LL: 2.35&nbsp;±&nbsp;3.1;p&nbsp;=&nbsp;0.9285). No significant correlation was observed between expression of the transcription factor and adhesion molecules analyzed. The synthesis of ICAM-1, VCAM-1 and CD62E depends on the activation of NFκB, which acts synergistically with other transcription factors. Adequate activation of intracellular signaling pathways results in the production of endothelial adhesion molecules, contributing to the recruitment of cells to the site of injury and thus eliciting an effective inflammatory response in the elimination of the bacillus.</p>
  a1096-1208