01899nas a2200241   4500000000100000008004100001653002300042653001200065653002200077653001100099653002900110100001300139700001800152700001400170700001400184700001600198700002100214700001400235245010000249300001200349520128200361022001401643       2018                            d10aPerformance status10aleprosy10aGene polymorphism10aCTLA-410aAge at the disease onset1 aAlmasi S1 aAliparasti MR1 aNaghili B1 aYeganeh K1 aTavanafar F1 aAmini-Khiabani S1 aBabaloo Z00aAnalysis of CTLA-4+49A/G gene polymorphism in cases with leprosy of Azerbaijan, Northwest Iran.  a121-1273 a<p>Leprosy, which is developed by the obligate intracellular Mycobacterium leprae (ML); has different manifestations, associated with the host immune responses. The protective immune response against ML includes T-cell-mediated immunity. The CTLA-4 has a great impact as a negative regulator of the immune response and maintenance of peripheral tolerance. This study analyzed the relationship between CTLA-4+49A/G gene polymorphism and clinical manifestation of leprosy disease and susceptibility among the Azeri population living Northwest Iran. One hundred and fifty- six leprosy patients and 185 healthy controls participated in the study. CTLA-4+49A/G genotyping was conducted via tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) analysis. The allelic and genotypic frequencies of +49A/G gene polymorphism were similar in controls and patients. However older age of onset and over-representation in male were observed in leprosy patient carriers of GG genotype. The current study demonstrates that although CTLA-4+49A/G polymorphism was not correlated with a higher genetic risk for leprosy, the presence of a GG genotype was associated with a older age of onset and over-representation in male in Iranian Azeri population.</p>
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