01482nas a2200169   4500000000100000008004100001100001400042700001100056700001400067700001300081245014700094856007600241300001200317490000600329520096300335022001401298       2017                            d1 aMohanty P1 aNaaz F1 aBansal AK1 aGupta UD00aAssessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640893/pdf/mbrc-6-113.pdf  a113-1220 v63 a<p>The emergence of drug resistance in leprosy is a major hurdle in leprosy elimination programme. Although the problem of drug resistance is presently not acute, it is important that we collect data more systematically and monitor the trend carefully so that effective measures to combat this problem can be developed. The present study aimed at the explication of cross resistance of rifabutin and rifapentine to rifampicin which would be helpful to programme managers for implementing rifabutin or rifapentine in replace of rifampicin. In this study we built 3D model of the M. leprae rpoB using Swiss Model and the modelled structure was docked with rifampicin, rifabutin and rifapentine. We established that these 3 antibiotics interact with the same binding region in the modelled rpoB of M. leprae. Thus we conclude that vocation of rifabutin and rifapentine could not be suitable in replace of rifampicin to combat with drug resistance leprosy.</p>
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