The purpose of this study was to compare the effects of two kinds of stretching - passive, static stretching, and proprioceptive neuromuscular facilitation (PNF) - in patients with leprosy sequel. Twelve patients were randomly assigned into two groups: the PNF group and the SS group, that was submitted to static stretching. Both groups attended ten stretching sessions, being submitted to initial and final evaluations in which were assessed: health-related quality of life, by means of he SF-36 questionnaire; ankle and wrist range of motion (ROM); and sensitivity and reflex testing. Improvements in ankle movement and in three SF-36 domains were observed in PNF group; and in five SF-36 domains in SS group. PNF group showed better improvement in wrist extension and ankle movement than SS group. PNF seems to be a more effective method to increase flexibility and ankle and wrist range of motion in patients with leprosy sequelae. No relation was found between ROM improvement and perception of better health-related quality of life in any of the groups.